Mechanism of Rhodanese Catalysis of Thiosulfate-Lipoate Oxidation-Reduction
نویسندگان
چکیده
منابع مشابه
Mechanism of Rhodanese Catalysis of Thiosulfate-lipoate Oxidation-reduction.
Crystalline beef liver rhodanese (thiosulfate : cyanidesulfurtransferase, EC 2.8.1.1) catalyzes sulfur transfer from SSOato CNby a double displacement mechanism (3, 4). The biological role of this reaction is not clear, but its possible involvement in CNdetoxication has been repeatedly stressed. The present study of the specificity of the crystalline beef liver enzyme and of the occurrence of t...
متن کاملRhodanese-catalyzed reduction of thiosulfate by reduced lipoic acid.
by a double displacement mechanism (1, 2). Thiosulfate and organic thiosulfonates will act as sulfur donors for the enzyme (3). Cyanide ion, SOS=, and the organic sulfinates will accept sulfur from the enzyme-sulfur compound (1, 4, 5). In this study, crystalline beef liver rhodanese has been found to catalyze the reduction of SSOp to HSand SOf. Several powerful reducing agents, such as NaBH4 an...
متن کاملAn expanded mechanism for rhodanese catalysis.
The kinetic behavior of rhodanese (thiosulfate: cyanide sulfurtransferase, EC 2.8.1.1) was investigated at pH values from 5.0 to 10.8. The binding of thiosulfate was shown to be dependent upon a pK’ of 9.9, with the protonated enzyme binding the substrate much more strongly than the deprotonated form. An enzymic nucleophile displaces sulfite to form the sulfur-substituted enzyme. This reaction ...
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removal of thiosulfate (s2o32-, 200 mg/l) from simulated wastewater samples was investigated under varying co-pollutants and ph conditions employing the titanium dioxide (tio2) mediated photocatalysis. for thiosulfate only studies higher substrate removal was noted at lower ph with a specific trend of ph 4 > ph 7 > ph 10. furthermore, near complete thiosulfate removal was also achieved at ph 4....
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)51822-6